Endocrine Abstracts

Objectives: The aim of this study was to analyze the prevalence of some polymorphisms of the CTR-AluI, VDR-FokI, Col1A1y ER-α genes, (involved in bone metabolism), in our population. And evaluate the association of these polymorphisms with bone mineral density and fracture.Design, Patients, and Setting: We performed an observational prospective study in pre- and postmenopausal ambulatory women (n=72 and n=152, respectively).<p ...

Aim: Bone turnover markers (BTMs) predict more rapid rates of bone loss. However, most of these studies have been carried out in postmenopausal women. Few prospective studies have examined the degradation marker C-terminal telopeptide of type I collagen (CTX) and the bone formation marker N-aminoterminal propeptide of type I collagen (P1NP) measured during the menopausal transition to predict the subsequent bone loss.Methods: We performed a prospective c...